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Transverse limb reduction defects after chorion villus sampling: A retrospective Cohort study
Author(s) -
Mastroiacovo Pierpaolo,
Tozzi Alberto Eugenio,
Agosti Silvano,
Bocchino Giancarlo,
Bovicelli Luciano,
Dalprà Leda,
Carbone Laura Doria Laba,
Lituania Mario,
Luttichau Angelica,
Mantegazza Franco,
Nocera Gianfranco,
Pachi Antonio,
Passamonti Ubaldo,
Piombo Giuseppe,
Vasta Anna Franca
Publication year - 1993
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970131109
Subject(s) - retrospective cohort study , medicine , reduction (mathematics) , obstetrics , chorionic villus sampling , pregnancy , fetus , surgery , prenatal diagnosis , biology , genetics , geometry , mathematics
A retrospective cohort study was performed in five Italian obstetrical centres from 1984 to 1991 in order to verify the association between chorionic villus sampling (CVS) and transverse limb reduction defects (TLRDs). TLRD rates by period of gestation at CVS were calculated, and the study's results were compared with data from the general population. Of the 3430 pregnancies for which CVS was performed, 2759 had a known outcome. The overall rate for TLRDs was 1 in 1143 CVS pregnancies, four times higher than that of the general population in Italy (1 in 4458). The rate of TLRDs was 2·9/1000 for CVS performed at 9 weeks' gestation and 1·0/1000 for CVS at 10 weeks' gestation. A scalp defect was detected in a pregnancy in which CVS was performed at 10 weeks. A high proportion of pregnancies lost to follow‐up and the poor quality of the data may have affected the results. Nevertheless, our results suggest an association between CVS carried out at less than 10 weeks' gestation and TLRDs which is consistent with the findings of other studies. CVS should not be prepared at less than 10 weeks' gestation until additional evidence is obtained.