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First‐trimester free beta (hCG) screening for Down syndrome
Author(s) -
Macri James N.,
Spencer Kevin,
Aitken David,
Garver Kenneth,
Buchanan Philip D.,
Muller Françoise,
Boue Andre
Publication year - 1993
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970130704
Subject(s) - pregnancy , down syndrome , medicine , beta (programming language) , first trimester , obstetrics , second trimester , gynecology , gestation , biology , genetics , computer science , psychiatry , programming language
Maternal serum free beta (hCG) levels are elevated (median 2·20 MOM) in the first trimester of pregnancy in 38 Down syndrome cases as compared with appropriate controls. This observation may form the basis for its use as a marker in screening for Down syndrome in the first trimester. Altered levels of the free beta analyte are observed in pregnancy conditions or complications other than Down syndrome.