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A prospective cytogenetic study of third‐trimester placentae in small‐for‐date but otherwise normal newborns
Author(s) -
Kennerknecht Ingo,
Krämer Sabine,
Grab Dieter,
Terinde Rainer,
Vogel Walther
Publication year - 1993
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970130405
Subject(s) - growth retardation , obstetrics , prospective cohort study , small for gestational age , pregnancy , medicine , placenta , first trimester , aneuploidy , gestational age , gestation , fetus , biology , genetics , chromosome , gene
Data in the literature suggest that confined placental mosaicism might be associated with intrauterine growth retardation. However, this association may be coincidental and due to bias of ascertainment. We therefore started a prospective study based on the cytogenetic evaluation of placentae derived from growth‐retarded newborns. We further minimized possible bias by excluding those small‐for‐date infants displaying findings which already could explain intrauterine growth retardation (mothers who are smokers, multiple pregnancies, gestosis, dysmorphic infants). In a collection of 71 small‐for‐gestational age newborns, we did not see a single case of true confined placental mosaicism.