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Low‐dose sulprostone for pregnancy termination in cases of fetal abnormality
Author(s) -
Kanhai Humphrey H. H.,
Keirse Marc J. N. C.
Publication year - 1993
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970130206
Subject(s) - medicine , regimen , pregnancy , fetus , obstetrics , placenta , pregnancy termination , anesthesia , gynecology , surgery , genetics , biology
Thirty‐two pregnancies (11 primi‐ and 21 multi‐gravid) with an abnormal fetus were terminated between 16 and 35 weeks (mean 22 weeks; median 20 weeks) and a continuous intravenous infusion of 1 μ g of the prostaglandin analogue sulprostone. All pregnancies were terminated vaginally, 31 of them with this regimen in a median induction‐expulsion interval of 23 h (range 8–52 h). Complete expulsion of the placenta occurred in 72 per cent of cases. Median blood loss was 100 ml (range 20–2000 ml). There were only a few side‐effects. We conclude that this induction regimen is both appropriate and safe for pregnancy termination in cases of fetal anomaly.