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CA‐125 as a maternal serum marker for Down's syndrome in the first and second trimesters
Author(s) -
Høgdall C. K.,
Høgdall E. V. S.,
Arends J.,
NørgaardPedersen B.,
SmidtJensen S.,
Larsen S. O.
Publication year - 1992
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970120312
Subject(s) - down syndrome , medicine , obstetrics , psychiatry
CA‐125, alpha‐fetoprotein (AFP), and human chorionic gonadotropin (HCG) were determined in maternal serum in the first trimester from 14 women with a Down's syndrome fetus and 61 women with a healthy fetus. In the second trimester, 15 and 60 serum samples were determined from women with a Down's syndrome and a healthy fetus respectively. In both trimesters, maternal serum CA‐125 was found to be elevated in Down's syndrome pregnancies compared with controls. Using discrimination functions, our preliminary results indicate that CA‐125 is a better marker than AFP and HCG respectively for a Down's syndrome fetus in the first trimester and improves the detection rate in the second trimester.