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Prenatal identification of small mosaic markers of different chromosomal origins
Author(s) -
Stetten Gail,
Blakemore Karin J.,
Courter Anne M.,
Coss Cathleen A.,
Jabs Ethylin Wang
Publication year - 1992
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970120203
Subject(s) - biology , centromere , marker chromosome , chromosome , genetics , karyotype , microbiology and biotechnology , cytogenetics , small supernumerary marker chromosome , genetic marker , hybridization probe , comparative genomic hybridization , aneuploidy , dna , gene
In situ hybridization using a series of alphoid DNA probes has demonstrated the origin of two small accessory mosaic marker chromosomes ascertained from 1079 amniocenteses. These markers appeared to be de novo , derived from acrocentric chromosomes, and identical by traditional cytogenetic staining (G, Q, C, AgNOR, Hoechst‐distamycin). Molecular characterization showed that one marker had originated from chromosome 14, the other from chromosome 22. Clinical outcome in both cases was normal.