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Heterochromatin decondensation in chromosomes from chorionic villus samples
Author(s) -
Pérez M. M.,
Míguez L.,
Fuster C.,
Miró R.,
Genescà A.,
Egozcue J.
Publication year - 1991
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970110906
Subject(s) - chorionic villi , heterochromatin , chorionic villus sampling , cytogenetics , karyotype , biology , aneuploidy , genetics , obstetrics , andrology , medicine , gynecology , prenatal diagnosis , chromosome , pregnancy , fetus , gene
The spontaneous decondensation of constitutive heterochromatic regions of chromosomes 1, 9, 16, and Y has been observed in 46.6 per cent of chorionic villus samples. This type of decondensation is occasionally observed in amniotic fluid cells (9 per cent) and has never been found in fetal lymphocytes. The phenomenon is similar to that described in spermatogonial metaphases, in primary and secondary spermatocytes and in human sperm chromosomes, although decondensation of the heterochromatin of chromosome 15 has never been recorded in chorionic villus samples.