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First‐trimester screening for fetal chromosomal abnormalities. Preliminary results
Author(s) -
van Lith J. M. M.
Publication year - 1991
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970110819
Subject(s) - fetus , gestation , alpha fetoprotein , down syndrome , medicine , obstetrics , first trimester , second trimester , prenatal diagnosis , gynecology , pregnancy , biology , genetics , psychiatry , hepatocellular carcinoma
We have started a multicentre trial to study the possibilities of first‐trimester maternal serum screening for fetal chromosomal abnormalities. Maternal blood samples were obtained before 13 weeks of gestation. We present the preliminary results of the first 950 patients on alpha‐fetoprotein (AFP). Results on cancer antigen 125 (CA 125) in Down's syndrome and normal pregnancies are also presented. We conclude that the results on AFP are promising and that CA 125 might be predictive for fetal Down's syndrome.