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Holoprosencephaly: Prenatal diagnosis by sonography and magnetic resonance imaging
Author(s) -
Tomà P.,
Costa A.,
Magnano G. M.,
Cariati M.,
Lituania M.
Publication year - 1990
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970100704
Subject(s) - holoprosencephaly , medicine , magnetic resonance imaging , prenatal diagnosis , fetus , pregnancy , radiology , differential diagnosis , ultrasound , autopsy , pathology , genetics , biology
Magnetic resonance (MR) imaging was performed on two women at the 33rd and 34th pregnancy week, respectively, after ultrasonographic detection of a brain malformation. Fetal neuromuscular blockade was induced by pancuronium bromide injected into the umbilical vein under continuous ultrasound (US) guidance. MR images supported the echotomographic diagnosis of holoprosencephaly, improving the image quality and offering additional information in such cases of difficult differential fetal diagnosis. Holoprosencephaly was finally confirmed by neonatal US and autopsy (case 1), US, CT and MR (case 2).