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A single chorionic gonadotropin assay for maternal serum screening for Down's syndrome
Author(s) -
Muller Françoise,
Boué André
Publication year - 1990
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970100606
Subject(s) - amniocentesis , trisomy , down syndrome , human chorionic gonadotropin , medicine , aneuploidy , gonadotropin , obstetrics , prenatal diagnosis , gynecology , pregnancy , immunoassay , andrology , fetus , biology , endocrinology , immunology , genetics , antibody , hormone , psychiatry , gene , chromosome
A simple enzyme immunoassay measuring human chorionic gonadotropin in undiluted maternal serum has been developed in order to be used as a prenatal screening test for Down' s syndrome. A retrospective study of maternal serum sampled during pregnancies associated with trisomy 21 shows that with a 5% amniocentesis rate determined on a single test, the detection rate of trisomy 21 would be around two‐thirds of the affected pregnancies. A prospective study of 9040 pregnant women under 38 years has confirmed the usefulness of the assay.