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First‐trimester maternal serum biochemical indicators in Down syndrome
Author(s) -
Brock D. J. H.,
Barron Lilias,
Holloway Susan,
Liston W. A.,
Hillier S. G.,
Seppala M.
Publication year - 1990
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970100406
Subject(s) - gestation , medicine , first trimester , pregnancy , down syndrome , alpha fetoprotein , alkaline phosphatase , obstetrics , endocrinology , gynecology , biology , enzyme , biochemistry , genetics , psychiatry , hepatocellular carcinoma
A set of 21 early maternal serum samples (19 first‐trimester and two at 14 weeks) from pregnancies resulting in a child with Down syndrome was matched for gestation and length of storage with 63 samples from unaffected pregnancies. The concentrations of alpha‐fetoprotein (AFP), unconjugated oestriol (uE 3 ), human chorionic gonadotrophin (hCG), pregnancy‐specific β 1 –glycoprotein (SP 1 ), and placental alkaline phosphatase (PALP) were measured. The ratios of the medians for Down syndrome pregnancies compared with the medians for controls were AFP 0·71, uE 3 0·67, hCG 1·43, SP 1 0·79, and PALP 0·92. Although the differences between the medians for affected and unaffected pregnancies were not significant, the trends for AFP, uE 3 , and hCG confirm earlier findings on first‐trimester samples.