First‐trimester maternal serum biochemical indicators in Down syndrome | Zendy

Brock D. J. H. | Zendy; Barron Lilias | Zendy; Holloway Susan | Zendy; Liston W. A. | Zendy; Hillier S. G. | Zendy; Seppala M. | Zendy

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First‐trimester maternal serum biochemical indicators in Down syndrome

Author(s) -

Brock D. J. H.,

Barron Lilias,

Holloway Susan,

Liston W. A.,

Hillier S. G.,

Seppala M.

Publication year - 1990

Publication title -

prenatal diagnosis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.956

H-Index - 97

eISSN - 1097-0223

pISSN - 0197-3851

DOI - 10.1002/pd.1970100406

Subject(s) - gestation , medicine , first trimester , pregnancy , down syndrome , alpha fetoprotein , alkaline phosphatase , obstetrics , endocrinology , gynecology , biology , enzyme , biochemistry , genetics , psychiatry , hepatocellular carcinoma

A set of 21 early maternal serum samples (19 first‐trimester and two at 14 weeks) from pregnancies resulting in a child with Down syndrome was matched for gestation and length of storage with 63 samples from unaffected pregnancies. The concentrations of alpha‐fetoprotein (AFP), unconjugated oestriol (uE 3 ), human chorionic gonadotrophin (hCG), pregnancy‐specific β 1 –glycoprotein (SP 1 ), and placental alkaline phosphatase (PALP) were measured. The ratios of the medians for Down syndrome pregnancies compared with the medians for controls were AFP 0·71, uE 3 0·67, hCG 1·43, SP 1 0·79, and PALP 0·92. Although the differences between the medians for affected and unaffected pregnancies were not significant, the trends for AFP, uE 3 , and hCG confirm earlier findings on first‐trimester samples.

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