Early amniocentesis: Experience of 222 consecutive patients, 1987–1988 | Zendy

Nevin J. | Zendy; Nevin N. C. | Zendy; Dornan J. C. | Zendy; Sim D. | Zendy; Armstrong M. J. | Zendy

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Early amniocentesis: Experience of 222 consecutive patients, 1987–1988

Author(s) -

Nevin J.,

Nevin N. C.,

Dornan J. C.,

Sim D.,

Armstrong M. J.

Publication year - 1990

Publication title -

prenatal diagnosis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.956

H-Index - 97

eISSN - 1097-0223

pISSN - 0197-3851

DOI - 10.1002/pd.1970100203

Subject(s) - amniocentesis , medicine , gestation , respiratory distress , obstetrics , abortion , amniotic fluid , prenatal diagnosis , abnormality , pregnancy , pneumonia , fetus , pediatrics , gynecology , surgery , biology , genetics , psychiatry

Early amniocentesis from 9 to 14 weeks' gestation provides a safe and accurate method of prenatal diagnosis of cytogenetic and biochemical disorders. There was a 100 per cent success rate in culturing the amniotic cells from 222 samples obtained between 9 and 14 weeks' gestation. Follow‐up of the patients to delivery revealed an abortion rate of 1·4 per cent. Among the 207 live‐ and stillborn infants, only one had a congenital abnormality (bilateral talipes equino‐varus) and no infant had respiratory distress syndrome or pneumonia. Eleven pregnancies were terminated following the detection of a chromosomal, biochemical, or congenital abnormality (5·0 per cent). However, before the procedure of early amniocentesis becomes routine clinical practice, it requires appraisal by a randomized clinical trial.

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