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Early amniocentesis: Experience of 222 consecutive patients, 1987–1988
Author(s) -
Nevin J.,
Nevin N. C.,
Dornan J. C.,
Sim D.,
Armstrong M. J.
Publication year - 1990
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970100203
Subject(s) - amniocentesis , medicine , gestation , respiratory distress , obstetrics , abortion , amniotic fluid , prenatal diagnosis , abnormality , pregnancy , pneumonia , fetus , pediatrics , gynecology , surgery , biology , genetics , psychiatry
Early amniocentesis from 9 to 14 weeks' gestation provides a safe and accurate method of prenatal diagnosis of cytogenetic and biochemical disorders. There was a 100 per cent success rate in culturing the amniotic cells from 222 samples obtained between 9 and 14 weeks' gestation. Follow‐up of the patients to delivery revealed an abortion rate of 1·4 per cent. Among the 207 live‐ and stillborn infants, only one had a congenital abnormality (bilateral talipes equino‐varus) and no infant had respiratory distress syndrome or pneumonia. Eleven pregnancies were terminated following the detection of a chromosomal, biochemical, or congenital abnormality (5·0 per cent). However, before the procedure of early amniocentesis becomes routine clinical practice, it requires appraisal by a randomized clinical trial.