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Autosomal dominant polycystic kidney disease: Prenatal diagnosis by DNA analysis and sonography at 14 weeks
Author(s) -
Ceccherini I.,
Lituania M.,
Cordone M. S.,
Perfumo F.,
Gusmano R.,
Callea F.,
Archidiacono N.,
Romeo G.
Publication year - 1989
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970091103
Subject(s) - prenatal diagnosis , polycystic kidney disease , medicine , kidney disease , autosomal dominant polycystic kidney disease , obstetrics , pathology , pregnancy , disease , fetus , genetics , biology
A pregnant woman affected with autosomal dominant polycystic kidney disease (ADPKD) had a history of an affected fetus, diagnosed by sonography at 29 weeks of pregnancy. The proband's father was also affected. DNA analysis performed on chorionic villi at 11 weeks during a second pregnancy predicted an affected fetus, and sonographic examination at 14 weeks confirmed the diagnosis.

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