Premium
Trisomic 22 placenta in a case of severe intrauterine growth retardation
Author(s) -
Stioui S.,
de Silvestris M.,
Molinari A.,
Stripparo L.,
Ghisoni L.,
Simoni G.
Publication year - 1989
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970090911
Subject(s) - growth retardation , placenta , placenta diseases , medicine , obstetrics , pregnancy , fetus , biology , genetics
We describe a case in which a trisomic 22 placenta could be the cause of severe growth retardation in a chromosomally normal female fetus. At amniocentesis a mosaic 46,XX/ 47,XX, +22 was observed in amniotic fluid specimens sampled on two different occasions, while fetal blood from a diagnostic cordocentesis revealed a normal chromosome constitution. Postnatal studies showed the consistent presence of trisomic 22 cells in the placenta, while only normal metaphases were found in amnion, blood, and fibroblast cultures.