Translocation trisomy 21 in CVS not found in embryoblast: Three different cell lines in CVS, amnion‐ and placental culture | Zendy

Eiben Bernd | Zendy; Hansen Susanne | Zendy; Knipping Jutta | Zendy; Massenberg Regina | Zendy; Goebel Richard | Zendy; Hammans Wilhelm | Zendy

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Translocation trisomy 21 in CVS not found in embryoblast: Three different cell lines in CVS, amnion‐ and placental culture

Author(s) -

Eiben Bernd,

Hansen Susanne,

Knipping Jutta,

Massenberg Regina,

Goebel Richard,

Hammans Wilhelm

Publication year - 1989

Publication title -

prenatal diagnosis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.956

H-Index - 97

eISSN - 1097-0223

pISSN - 0197-3851

DOI - 10.1002/pd.1970090511

Subject(s) - karyotype , amniocentesis , chromosomal translocation , trisomy , amnion , chorionic villi , prenatal diagnosis , andrology , biology , aneuploidy , cord blood , pregnancy , gynecology , fetus , obstetrics , medicine , chromosome , genetics , gene

Chorionic villus samples from a healthy pregnant female were obtained for first‐trimester prenatal diagnosis. A translocation trisomy 21 was diagnosed. A consecutive amniocentesis revealed a normal male karyotype. At term a healthy boy was born. Cytogenetic analysis from cord blood showed a regular karyotype of 46,XY, whereas in term placenta a pathological karyotype of 47,XY,+mar was found.

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