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Translocation trisomy 21 in CVS not found in embryoblast: Three different cell lines in CVS, amnion‐ and placental culture
Author(s) -
Eiben Bernd,
Hansen Susanne,
Knipping Jutta,
Massenberg Regina,
Goebel Richard,
Hammans Wilhelm
Publication year - 1989
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970090511
Subject(s) - karyotype , amniocentesis , chromosomal translocation , trisomy , amnion , chorionic villi , prenatal diagnosis , andrology , biology , aneuploidy , cord blood , pregnancy , gynecology , fetus , obstetrics , medicine , chromosome , genetics , gene
Chorionic villus samples from a healthy pregnant female were obtained for first‐trimester prenatal diagnosis. A translocation trisomy 21 was diagnosed. A consecutive amniocentesis revealed a normal male karyotype. At term a healthy boy was born. Cytogenetic analysis from cord blood showed a regular karyotype of 46,XY, whereas in term placenta a pathological karyotype of 47,XY,+mar was found.