Premium
Practical experience using transabdominal chorionic villus biopsies taken after 16 weeks' gestation for rapid prenatal diagnosis of chromosomal abnormalities
Author(s) -
Wolstenholme J.,
Hoogwerf A. M.,
Sheridan H.,
Maher E. J.,
Little D. J.
Publication year - 1989
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970090509
Subject(s) - gestation , prenatal diagnosis , chorionic villus sampling , obstetrics , chorionic villi , medicine , fetus , amniocentesis , pregnancy , gynecology , biology , genetics
Placental biopsy was performed on 81 patients at greater than 16 weeks' gestation. The major indication for such biopsies was an increased risk of chromosomal abnormality because of either abnormal ultrasound findings or late presentations for advanced maternal age. Six abnormal karyotypes resulting in elective termination were found. The use of rapid karyotyping by this procedure as an alternative to amniocentesis or fetal blood sampling is discussed.