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Congenital cystic hygroma of the neck diagnosed prenatally: Outcome with normal and abnormal karyotype
Author(s) -
Abramowicz Jacques S.,
Warsof Steven L.,
Doyle Debra Lochner,
Smith Deborah,
Levy Donald L.
Publication year - 1989
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970090504
Subject(s) - cystic hygroma , karyotype , in utero , medicine , fetus , pediatrics , prenatal diagnosis , pregnancy , obstetrics , chromosome , biology , genetics , gene
Twenty‐two cases of cystic hygromas were diagnosed prenatally at Eastern Virginia Medical School and followed through the neonatal period. Our series was combined with 131 cases which have been described in the literature. Karyotypes were obtained in 110 fetuses and 80 (72·7 per cent) were abnormal. Fifty‐one were not terminated: 30 with abnormal and 21 with normal karyotypes. There were no neonatal survivors in the group with abnormal karyotypes. There were five survivors in the 21 with normal karyotypes but only 2/21 without severe medical complications. Combining our series with those previously reported in the literature would suggest only a 2–3 per cent rate of intact survivors when fetal cystic hygromas are diagnosed in utero . This information should be helpful when counselling patients whose pregnancies carry this diagnosis.