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First‐trimester amniotic fluid acetylcholinesterase electrophoresis
Author(s) -
Muller F.,
Oury J. F.,
Boue A.
Publication year - 1989
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970090305
Subject(s) - acetylcholinesterase , amniotic fluid , aché , neural tube , pregnancy , medicine , prenatal diagnosis , second trimester , first trimester , fetus , andrology , chemistry , biology , enzyme , biochemistry , embryo , genetics
Acetylcholinesterase (AChE) gel electrophoresis was performed on normal amniotic fluids obtained at 4–15 weeks of pregnancy. Until 8 weeks, all the fluids were AChE‐positive; the percentage of positive specimens decreased from 9 until 11 weeks and no positive specimen was found after 12 weeks. This method may allow early prenatal dignosis of neural tube defects after the 12th week.