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False‐negative amniotic fluid acetylcholinesterase in a case of meningo‐encephalocele
Author(s) -
Boogert A.,
Aarnoudse J. G.,
de Bruijn H. W. A.,
Gouw A.
Publication year - 1989
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970090209
Subject(s) - amniotic fluid , encephalocele , ventriculomegaly , acetylcholinesterase , gestation , medicine , autopsy , pathology , fetus , anatomy , pregnancy , biology , enzyme , biochemistry , genetics
We describe a patient with a significantly elevated serum alphafetoprotein (AFP) concentration at 17 weeks of gestation, who showed only a marginally increased amniotic fluid AFP and lacked the second rapidly migrating band of acetylcholinesterase electrophoresis. Ultrasound examination revealed an encephalocele and ventriculomegaly. Autopsy showed that the encephalocele was not covered by skin.

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