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Prenatal diagnosis of cystic fibrosis: Ultrasonographic appearance of meconium ileus in the fetus
Author(s) -
Caspi Benjamin,
Elchalal Uri,
Lancet Moshe,
Chemke Juan
Publication year - 1988
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970080508
Subject(s) - cystic fibrosis , meconium ileus , amniocentesis , medicine , meconium , fetus , prenatal diagnosis , amniotic fluid , autopsy , obstetrics , gestation , pregnancy , pathology , biology , genetics
Four often fetuses carrying a risk of 1:4 for cystic fibrosis were found to have low levels of microvillar enzymes in the amniotic fluid obtained between 17 and 18 weeks' gestational age. On sonography performed prior to the amniocentesis, three fetuses showed enlarged bowel loops. At autopsy, meconium ileus was detected. Enlarged bowel loops are a sign which has not been described previously so early in pregnancies.