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Intrauterine hypercalcaemia and non‐immune hydrops fetalis— relationship to the Williams syndrome
Author(s) -
Westgren M.,
Eastham W. N.,
Ghandourah S.,
Woodhouse N.
Publication year - 1988
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970080504
Subject(s) - medicine , hypercalcaemia , calcification , fetus , cord blood , parathyroid hormone , vitamin d and neurology , hydrops fetalis , endocrinology , pregnancy , calcium , biology , genetics
We describe a 28‐week‐old fetus with severe non‐immune hydrpps. Intrauterine cord blood sampling revealed hypercalcaemia of 3–4mmol/l ( n = 2·6±0·1). Subsequently, a postmortem examination revealed supravalvular aortic and pulmonary artery stenosis together with extensive arterial calcification. The maternal calcium, 25‐hydroxyvitamin D 3 , 1,25‐dihydroxyvitamin D 3 , and parathyroid hormone levels were normal at delivery. This is the first time that hypercalcaemia has been diagnosed in vitro . We speculate on the fact that the disorder resulted as a consequence of abnormal vitamin D metabolism in the fetoplacental unit, and that it might be related to the Williams syndrome.