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Prenatal diagnosis of a de novo unbalanced translocation (4p + ) following in vitro fertilization
Author(s) -
Cannizzaro Linda A.,
Hecht Barbara K.,
Bixenman Helen A.,
Pazdziorko Stephen,
Tamis Robert,
Hecht Frederick
Publication year - 1988
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970080409
Subject(s) - chromosomal translocation , in vitro fertilisation , human fertilization , prenatal diagnosis , andrology , biology , medicine , genetics , pregnancy , fetus , gene
We report herein a de novo unbalanced chromosome translocation in a fetus resulting from in vitro fertilization technology. Prenatal diagnostic analysis of an amniotic fluid revealed a 46,XX,4p+ karyotype. The origin of the extra material on the short arm of chromosome 4 could not be identified by a variety of banding techniques. However, examination of fetal parts did reveal some dysmorphic features.