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Prenatal diagnosis of del(11)(p13p15)
Author(s) -
Stern Robert J.,
Hunter William S.,
Moross Tessa,
Gardner H. Allen
Publication year - 1988
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970080102
Subject(s) - aniridia , prenatal diagnosis , fetus , gestation , amniotic fluid , medicine , obstetrics , gestational age , pathological , pregnancy , gynecology , pathology , biology , genetics , gene
Prenatal diagnosis of del(11)(p13p15) was made on cultured amniotic fluid cells and confirmed on fetal skin fibroblasts after termination of pregnancy. Both irides appeared behind schedule in development by 2–3 weeks in reference to the gestational age of the fetus. It is suggested that the aniridia of the aniridia‐Wilms tumour association is due to developmental arrest. Confirmation of this complex is difficult at mid‐gestation without critical pathological study of the eyes.