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Comparison of maternal and fetal chromosome heteromorphisms to monitor maternal cell contamination in chorionic villus samples
Author(s) -
Olson Susan,
Buckmaster John,
Bissonnette John,
Magenis Ellen
Publication year - 1987
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970070607
Subject(s) - chorionic villus sampling , chorionic villi , obstetrics , medicine , pregnancy , gynecology , prenatal diagnosis , fetus , biology , genetics
Maternal cell contamination (MCC) presents a potential problem in the analysis of chorionic villus sampling (CVS) preparations for early prenatal diagnosis by chromosomal, biochemical and molecular methods. Through the comparison of fluorescent chromosome variants from CVS and maternal cells, we found three out of 50 samples to have MCC. One of these was observed on a direct preparation. Routine chromosome heteromorphism analysis suggested as a reliable method for monitoring MCC in CVS specimens.