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Neural tube defects in trisomy 18
Author(s) -
Flannery David B.,
Kahler Stephen G.
Publication year - 1986
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970060204
Subject(s) - neural tube , trisomy , amniocentesis , neural tube defect , incidence (geometry) , aneuploidy , prenatal diagnosis , fetus , karyotype , medicine , obstetrics , down syndrome , biology , pregnancy , genetics , chromosome , embryo , physics , gene , optics
In a retrospective survey, the incidence of neural tube defects in liveborn trimsomy 18 was found to be 6·2 per cent. Based on these data one would expect to find trisomy 18 in 1 of the 117 patients with myeloidysplasia; the incidence of trisomy 18 in dysraphic fetuses would be anticipated to be higher. These observations underscore the need for amniocentesis karyotyping of fetuses with neural tube defects, and the importance of careful examination of infants born with neural tube defects.