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First‐trimester prenatal diagnosis of severe alpha‐thalassemia
Author(s) -
Liming Wang,
Junwu Zhang,
Guanyun Wu,
Shenwu Wang,
Yu Fan,
Youwen Huang,
Letian Zhao,
Rongxin Wang,
Jidong Su,
Nijia Zhang,
Guifang Long,
Peng Li Qi, Zou,
Rong Liang,
Xu Liang
Publication year - 1986
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970060203
Subject(s) - prenatal diagnosis , thalassemia , alpha thalassemia , medicine , beta thalassemia , obstetrics , pediatrics , pregnancy , hemoglobinopathy , alpha (finance) , fetus , surgery , hemolytic anemia , genetics , biology , genotype , gene , construct validity , patient satisfaction
Abstract By means of chorion biopsy together with restriction endonuclease analysis of fetal DNA, first trimester diagnoses were successfully made in 33 fetuses at risk for Bart's hydrops fetalis. Seven pregnancies with Hb H or hydrops fetalis were therapeutically terminated before 4 months of gestation. Of the 26 pregnancies intended to continue, 18 have come to term with normal deliveries; one with threatened abortion was terminated at the end of the first trimester and, seven are progresssing normally.