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Chorionic villi sampling changes maternal serum alpha‐fetoprotein
Author(s) -
Mariona Federico G.,
Bhatia Rupi,
Syner Frank N.,
Koppitch Frederick
Publication year - 1986
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970060110
Subject(s) - chorionic villus sampling , amniocentesis , chorionic villi , obstetrics , prenatal diagnosis , medicine , abortion , sampling (signal processing) , alpha fetoprotein , pregnancy , gynecology , fetus , andrology , biology , genetics , filter (signal processing) , computer science , hepatocellular carcinoma , computer vision
Abstract Second trimester amniocentesis has traditionally been utilized for prenatal genetic diagnosis. Chorionic villi sampling (CVS) is presently offered as an alternative. The occurrence of fetomaternal bleed (FMB) during CVS could increase the rate of post sampling abortion and, additionally, be of significance in patients at risk for isoimmunization. Detection and quantitation of FMB can be accomplished by the determination of changes in maternal serum alpha‐fetoprotein (MSAFP) before and after CVS.

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