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Prenatal diagnosis and fetal pathology of partial trisomy 20p–monosomy 4p resulting from paternal translocation
Author(s) -
Vamos E.,
Pratola D.,
Van Regemorter N.,
Freund M.,
FlamentDurand J.,
Rodesch F.
Publication year - 1985
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970050308
Subject(s) - oligohydramnios , monosomy , amniocentesis , trisomy , chromosomal translocation , hypoplasia , prenatal diagnosis , fetus , aneuploidy , medicine , pregnancy , karyotype , obstetrics , gynecology , biology , anatomy , chromosome , genetics , gene
Amniocentesis was performed in view of a paternal balanced chromosomal rearrangement t(4;20)(p16;p12), inv(18)(p11q11). The pregnancy was complicated by severe oligohydramnios. The fetal karyotype was unbalanced: 46XX, der(4), t(4;20)(p16;p12), inv(18) (p11q11)pat., thus resulting in partial trisomy 2Op and monosomy 4p. In addition, the amniotic fluid alpha‐fetoprotein (AFP) became increasingly elevated with gestational age. The pregnancy was terminated at 25 weeks. The fetus presented with typical facial dysmorphic features, unilateral cleft lip and palate, severe renal hypoplasia, consistent with the 4p‐ (Wolf‐Hirschhorn) syndrome.