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Disaccharidase deficiency in amniotic fluid from cases of cystic fibrosis
Author(s) -
Schwartz Marianne,
Brandt Niels Jacob
Publication year - 1985
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970050208
Subject(s) - disaccharidase , cystic fibrosis , amniotic fluid , medicine , prenatal diagnosis , gastroenterology , pregnancy , fetus , biology , genetics , small intestine
The activities of the disaccharidases maltase and sucrase in 4 amniotic fluid from cystic fibrosis (CF) pregnancies have been compared to those of 120 non CF‐pregnancies. Very low levels were found in 3 of the CF‐fluids. The fourth CF‐fluid was normal in all measured microvillar enzyme activities. Elevated levels of disaccharidases in meconium from one of the patients born with CF, supports the idea that these enzymes are trapped in the intestinal cavity by sticky meconium.