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Prenatal diagnosis of cystic fibrosis. II. Meconium ileus in affected fetuses
Author(s) -
Muller F.,
Aubry M. C.,
Gasser B.,
Duchatel F.,
Boué J.,
Boué A.
Publication year - 1985
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970050204
Subject(s) - meconium ileus , cystic fibrosis , meconium , medicine , prenatal diagnosis , amniocentesis , fetus , pathological , obstetrics , pathology , pregnancy , biology , genetics
Meconium ileus was the presenting feature of cystic fibrosis in 46 per cent of the couples which have been referred for prenatal diagnosis. In fetuses which have been aborted on the basis of alkaline phosphatase isoenzymes assays, meconium ileus represented the only pathological feature of cystic fibrosis, and was observed in three fourths of the cases. Real‐time sonographic examination of fetuses at the time of amniocentesis was able to show an echogenic mass in the abdomen corresponding to the meconium ileus, and thus may afford a complementary means of diagnosis.