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Genetic amniocentesis in multiple gestations
Author(s) -
Filkins Karen,
Russo Joseph,
Brown Thomas,
Schmerler Susan,
Searle Bernard
Publication year - 1984
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970040311
Subject(s) - amniocentesis , gestation , obstetrics , chorionic villus sampling , trisomy , fetus , prenatal diagnosis , medicine , gynecology , aneuploidy , pregnancy , biology , genetics , chromosome , gene
Thirty‐one genetic amniocenteses involving multiple gestations were performed in the genetics unit between 1976 and 1982. Three sets of triplets were included. Precise locations of the sacs were determined using real‐time ultrasonography and successful sampling of all sacs was accomplished. Spontaneous abortions occurred in two normal twins and one normal triplet gestation. Two therapeutic abortions were performed for fetal abnormalities. Two cases of discordance for trisomy 21 (one twin and one triplet) were allowed to continue; the twin case terminated at 25 weeks' gestation with neonatal deaths and the triplets are alive and well.