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Prenatal diagnosis of thalassaemia by haemoglobin chromatography on biorex an evaluation of the method
Author(s) -
Dash Sumitra,
Panourgias John,
Karababa Photini,
Loukopoulos Dimitris
Publication year - 1984
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970040103
Subject(s) - prenatal diagnosis , fetal hemoglobin , beta thalassaemia , medicine , chromatography , globin , thalassemia , fetus , pregnancy , chemistry , hemoglobin , biology , genetics
The applicability of the chromatographic separation of haemoglobins F, A and S on Biorex 70 (Blouquit et al. , 1982) for the prenatal diagnosis of thalassaemia and related conditions was evaluated in comparison to the conventional globin chain separation technique. The method proved reliable, inexpensive and rapid and should be considered as a valuable alternative in laboratories carrying out great numbers of tests and those being newly set up for this purpose.