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Limited use of chromosomal markers in prenatal diagnosis
Author(s) -
Friedrich Ursula,
Jensen Peter K. A.
Publication year - 1983
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970030414
Subject(s) - chromosomal translocation , centromere , marker chromosome , biology , genetics , chromosome , prenatal diagnosis , robertsonian translocation , karyotype , fetus , pregnancy , gene
By aid of fluorescent centromere markers in chromosome No. 3 it could be shown that crossing over in a translocation quadrivalent had occurred on two occasions in a father who is carrier of a 3/5 translocation. This case demonstrates that marker chromosomes cannot always be used to trace the parental origin of structurally abnormal chromosomes.