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Amniotic fluid fibrinolytic system in fetal neural tube defects
Author(s) -
Legge Michael
Publication year - 1983
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970030212
Subject(s) - anencephaly , spina bifida , amniotic fluid , medicine , neural tube , fetus , obstetrics , fibrinolysis , prenatal diagnosis , pregnancy , andrology , embryo , biology , surgery , genetics
Second trimester amniotic fluid fibrinolytic system was examined in normal pregnancies and those complicated by anencephaly, spina bifida and fetal chromosome abnormalities. No significant difference was demonstrated between the fibrinolytic systems from normal pregnancies and those complicated by fetal chromosome abnormalities. In pregnancies complicated with anencephaly and spina bifida no significant difference was demonstrated for alpha‐1‐antitrypsin, alpha‐1‐antichymotrypsin and urokinase. Plasminogen was significantly lower (p < 0.02) and plasmin significantly higher ( p < 0.001) than levels from normal amniotic fluid. Alpha‐2‐macroglobulin, fibrinogen, FDP‐D and FDP‐E were detected only in pregnancies complicated with anencephaly and spina bifida.