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Prevention of neural tube defects in curly‐tail mice by maternal administration of vitamin A
Author(s) -
Seller Mary J.,
Perkins Kathleen I.
Publication year - 1982
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970020409
Subject(s) - neural tube , pregnancy , vitamin , medicine , fetus , neural tube defect , endocrinology , gestation , physiology , embryo , biology , genetics
Various doses of vitamin A were administered on day 9 of pregnancy to the pregnant curly‐tail mouse, a mutant, 60 per cent of which have neural tube defects (NTD). There was a reduction in the incidence of NTD in the fetuses with all doses used. The effect was maximal with 5 mg/kg; it was also marked, but to a lesser degree, with 10 and 20 mg/kg and minimal with 1 mg/kg. The implications of these findings in the mouse to the prevention of NTD in humans by preconception vitamin supplementation are discussed.