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Rh isoimmunization following genetic amniocentesis
Author(s) -
Golbus Mitchell S.,
Stephens John D.,
Cann Howard M.,
Mann John,
Hensleigh Paul A.
Publication year - 1982
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970020302
Subject(s) - amniocentesis , rh isoimmunization , medicine , obstetrics , rh blood group system , pregnancy , gynecology , fetus , prenatal diagnosis , antibody , immunology , biology , genetics
A series of 8009 genetic amniocenteses were retrospectively examined to evaluate the relationship of the procedure to Rh isoimmunization. Of the 615 Rh negative women giving birth to Rh positive infants and estimated to be at risk, thirteen (2·1 per cent) were sensitized subsequent to the amniocentesis. Eleven of the sensitizations occurred early in the programs, and a combination of experience and ultrasound performed concurrently with the amniocentesis appear to have reduced the risk of isoimmunization to that of control data from the literature.