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Prenatal diagnosis of trisomy 18 mosaicism
Author(s) -
Grass Frank S.,
Hisley John C.,
Parke James C.,
Bunn David
Publication year - 1982
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970020113
Subject(s) - trisomy , amniotic fluid , prenatal diagnosis , aneuploidy , fetus , amniocentesis , aborted fetus , karyotype , andrology , obstetrics , down syndrome , chromosome , biology , cell free fetal dna , medicine , pregnancy , genetics , gene
Trisorny 18 mosaicism was found in multiple primary cultures of amniotic fluid cells and subsequently confirmed by chromosome analysis of several tissues derived from the aborted fetus. The overall frequency of the minority cell line was 25 per cent in the amniotic fluid cultures and 28 per cent in the fetal tissues although much intertissue variations were noted.