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Fetal marfan syndrome: Prenatal ultrasound diagnosis with pathological confirmation of skeletal and aortic lesions
Author(s) -
Koenigsberg Mordecai,
Factor Stephen,
Cho Sangho,
Herskowitz Ahvie,
Nitowsky Harold,
Morecki Rachel
Publication year - 1981
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970010403
Subject(s) - medicine , marfan syndrome , pathological , fetus , prenatal diagnosis , pregnancy , ultrasound , ascending aorta , aorta , obstetrics , radiology , pathology , cardiology , biology , genetics
Sonography was performed during the second trimester in two pregnancies at risk for the Marfan syndrome. In one, the limbs were significantly longer than expected ( p < 0·0025) and a diagnosis of the Marfan syndrome was established. Pathological examination of the fetus after pregnancy interruption showed typical foci of cystic medial necrosis in the ascending aorta.