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Maternal environment and the expression of murine neural tube defects
Author(s) -
Seller Mary J.,
Beck Susan E.,
Adinolfi Matteo,
Polani Paul E.
Publication year - 1981
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970010204
Subject(s) - exencephaly , neural tube , neural tube defect , spina bifida , embryo , biology , mutant , anencephaly , fetus , anatomy , tube (container) , andrology , genetics , pregnancy , medicine , teratology , gene , materials science , composite material
The role that genetic and environmental factors play in triggering neural tube defects in the mouse mutant curly‐tail ( ct ) were investigated by transplanting curly‐tail blastocysts into the uterus of either curly‐tail females or females of an unrelated A strain with a low natural incidence of abnormalities of the neural tube. The percentages of fetuses with neural tube defects were found to be similar in both groups. These results show that in curly‐tail mice exencephaly and spina bifida are manifested independently of the maternal environment.