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Alphafetoprotein, cholinesterases and rapidly adhering cells in the prenatal diagnosis of neural tube defects
Author(s) -
Seller Mary J.,
Cole Kathleen J.,
Merritt Bernadette L.
Publication year - 1981
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1970010104
Subject(s) - neural tube , amniotic fluid , prenatal diagnosis , fetus , abnormality , tube (container) , neural tube defect , pathology , medicine , anatomy , biology , pregnancy , embryo , microbiology and biotechnology , materials science , genetics , psychiatry , composite material
Amniotic fluid cholinesterases tested on polyacrylamide gel and rapidly adhering cell analysis were compared in their efficiency at diagnosing fetal neural tube defects in three cases where the alphafetoprotein results were equivocal. While rapidly adhering cells were also equivocal, the cholinesterases consistently gave a clear indication of fetal abnormality.