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Failure of second‐trimester measurement of soluble endoglin and other angiogenic factors to predict placental abruption
Author(s) -
Tikkanen Minna,
Stenman UlfHåkan,
Nuutila Mika,
Paavonen Jorma,
Hiilesmaa Vilho,
Ylikorkala Olavi
Publication year - 2007
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1869
Subject(s) - placental growth factor , placental abruption , medicine , gestational age , obstetrics , gestation , endocrinology , pregnancy , vascular endothelial growth factor , vegf receptors , biology , genetics
Objective High level of soluble endoglin (sEng), a potent antiangiogenic factor, predicts pre‐eclampsia. We compared the serum levels of sEng in early second trimester in women with and without subsequent placental abruption. Proangiogenic placental growth factor (PlGF) and antiangiogenic soluble fms‐like tyrosine kinase 1 (sFlt‐1) were also studied. Methods Serum samples of 42 women with placental abruption and 50 control women, collected at 15 to 16 gestational weeks were analyzed for sEng, sFlt‐1 and PlGF by immunoassays. Results The levels of sEng showed no difference between the cases and controls, but parous or smoking women with abruption had lower levels of sEng. Similarly, sFlt‐1, PlGF, or sFlt‐1/PlGF ratio showed no difference between the cases and the controls. Conclusion Our data suggest that sEng, PlGF and sFlt‐1 levels in early second trimester fail to predict placental abruption. Copyright © 2007 John Wiley & Sons, Ltd.