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Color Doppler ultrasound of spiral artery blood flow for prediction of hypertensive disorders and intra uterine growth restriction: a longitudinal study
Author(s) -
Deurloo K. L.,
Spreeuwenberg M. D.,
Bolte A. C.,
Van Vugt J. M. G.
Publication year - 2007
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1822
Subject(s) - gestation , medicine , preeclampsia , uterine artery , intrauterine growth restriction , gestational age , blood flow , fetus , pregnancy , obstetrics , cardiology , biology , genetics
Objective To construct reference ranges for spiral artery (SA) flow velocities and examine the possibility to predict intra uterine growth restricted (IUGR) fetuses, pregnancy‐induced hypertension (PIH) and/or preeclampsia. Methods Spiral artery flow velocity measurements were performed using Color Doppler between 11 to 13 + 6, between 14 to 17 + 6 and between 18 to 24 weeks of gestation, each measurement was performed twice. Spiral artery flow velocities were analyzed with multilevel modeling: individual regression curves were estimated and combined to obtain the reference intervals for SA flow velocities in normal pregnancies. Mann–Whitney U tests was used to compare the deviation from expected flow velocity between normal and complicated pregnancies. Results One hundred and eight pregnancies were included; 4 pregnancies were complicated with preeclampsia, 10 pregnancies with IUGR fetuses (