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Maternal serum free ß‐hCG and PAPP‐A in patients with habitual abortion‐influence on first‐trimester screening for chromosomal abnormalities
Author(s) -
Heinig J.,
Steinhard J.,
Schmitz R.,
Nofer J.R.,
Kiesel L.,
Klockenbusch W.
Publication year - 2007
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1779
Subject(s) - trisomy , medicine , abortion , obstetrics , pregnancy associated plasma protein a , down syndrome , pregnancy , first trimester , gynecology , retrospective cohort study , aneuploidy , second trimester , fetus , biology , chromosome , biochemistry , genetics , psychiatry , gene
Objective To explore if maternal serum free ß‐hCG and pregnancy‐associated plasma protein A (PAPP‐A) levels in the first‐trimester of pregnancy are altered in patients with habitual abortions and if there is an effect on first‐trimester screening for Down syndrome. Methods A retrospective study was conducted on 913 normal singleton fetuses that underwent first‐trimester combined screening for Down syndrome. Maternal serum PAPP‐A and free β‐hCG were compared between patients with ( n = 64) and without habitual abortions ( n = 849). Results The medians ± SD log 10 MoM of PAPP‐A and free β‐hCG ± SD in patients with and without habitual abortions were 0.063 ± 0.28 versus − 0.014 ± 0.27 and − 0.001 ± 0.27 versus − 0.018 ± 0.31, with a p value of 0.042 and 0.87, respectively. The screen positive rate setting the cut off at 1:350 looking at the background risk for trisomy 21 was 71.4% in women with and 81.2% in women without habitual abortion, after combined first‐trimester screening it was 7.8% in women with and 10.1% in women without recurrent abortion. Conclusions Patients with habitual abortions have slightly increased maternal serum PAPP‐A levels in the first‐trimester. This marginal difference seems not to effect risk calculation in combined first‐trimester screening for trisomy 21. Copyright © 2007 John Wiley & Sons, Ltd.