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Complete chorioamniotic membrane separation with fetal restrictive dermopathy in two consecutive pregnancies
Author(s) -
Kim Young Nam,
Jeong Dae Hoon,
Jeong Su Jeon,
Sung Moon Su,
Kang Mi Seon,
Kim Ki Tae
Publication year - 2007
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1673
Subject(s) - medicine , amnion , oligohydramnios , fetus , gestation , polyhydramnios , obstetrics , pregnancy , muscle contracture , amniocentesis , prenatal diagnosis , surgery , genetics , biology
Objective To describe an instance of complete chorion‐amnion membrane separation with fetal restrictive dermopathy in two consecutive pregnancies. Methods We performed prenatal ultrasounds in two consecutive pregnancies and evaluated gross and microscopic postnatal findings. Results The first pregnancy ended at 32 weeks of gestation with spontaneous chorioamniotic membrane separation and preterm premature rupture of membranes. The mother delivered an abnormal male infant with generalized fixed joint contractures, rigid and shiny skin, skin laceration around the neck, a rounded and opened mouth, and palpebral conjunctival eversion. The subsequent pregnancy was also complicated by spontaneous complete chorioamniotic membrane separation, oligohydramnios, and fetal growth restriction at 26 + 3 weeks of gestation. A immaturely born second baby also carried multiple anomalies similar to those of the first. Both infants died shortly after birth. After microscopic examination of the skin, we diagnosed the infant as restrictive dermopathy. Conclusions Complete separation of the chorion‐amnion membrane may be regarded as a serious prenatal condition. Restrictive dermopathy or skin disorders caused by defects in collagen or elastic tissue metabolism may be one of the many causes of chorion‐amnion separation. Copyright © 2007 John Wiley & Sons, Ltd.