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Age‐specific risk of fetal loss post second trimester amniocentesis: analysis of 5043 cases
Author(s) -
Mazza Vincenzo,
Pati Mariangela,
Bertucci Emma,
Re Claudia,
Ranzi Andrea,
Percesepe Antonio,
Forabosco Antonino,
Volpe Annibale
Publication year - 2007
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1647
Subject(s) - amniocentesis , medicine , obstetrics , fetus , gestational age , pregnancy , second trimester , gestation , gynecology , amniotic fluid , prenatal diagnosis , biology , genetics
Objectives To assess the risk of fetal loss attributable to second trimester amniocentesis in singleton pregnancies through a cross‐sectional study. Methods Records of 5043 consecutive second trimester amniocentesis, performed by a single operator between 1997 and 2003, were analyzed. Fetal loss post amniocentesis was calculated by grouping pregnant women in age classes and assessing observed/expected (O/E) rate. Results Total fetal losses were 40 (0.81%): 33 cases (0.67%) occurred before the 24th week, 37 cases (0.76%) before the 28th gestational week, and 3 cases (0.06%) after the 28th week of pregnancy. An age‐dependent increase of the rate of fetal loss, not statistically significant (Chi‐Square = 0.349, p = 0.505) was observed. The total O/E ratio values did not show any statistically significant risk (O/E ratio = 1.25, CI = 0.86–1.64). The analysis of the single age classes did not detect any statistical significance. The excess fetal loss rate associated with amniocentesis was 0.16%. Conclusions No effect of the 2nd trimester amniocentesis was noted on fetal loss. Copyright © 2007 John Wiley & Sons, Ltd.