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Two‐ or three‐dimensional ultrasonography to predict pulmonary hypoplasia in pregnancies complicated by preterm premature rupture of the membranes
Author(s) -
Gerards Franca A.,
Twisk Jos W. R.,
Fetter Willem P. F.,
Wijnaendts Liliane C. D.,
Van Vugt John M. G.
Publication year - 2007
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1646
Subject(s) - pulmonary hypoplasia , medicine , hypoplasia , gestational age , lung , lung volumes , prospective cohort study , gestation , obstetrics , pregnancy , premature rupture of membranes , radiology , genetics , biology
Objectives The purpose of this study was to compare 3D lung volume measurements with 2D biometric parameters in predicting pulmonary hypoplasia in pregnancies complicated by preterm premature rupture of the membranes (PPROM). Methods In this prospective study, 18 pregnancies complicated by PPROMs at a mean 21 weeks' gestation (range 14–32 weeks) were examined. The 3D lung volume measurements and the following 2D biometric parameters were measured: thoracic circumference (TC) versus gestational age or femur length (FL), the TC/abdominal circumference (AC) ratio and the thoracic area/heart area (TA/HA) ratio. The sensitivity, specificity, positive and negative predictive value of each measurement to diagnose pulmonary hypoplasia were compared. Pulmonary hypoplasia was diagnosed on the basis of clinical, radiological and/or pathologic criteria. Results The incidence of pulmonary hypoplasia was 33.3%. The best diagnostic accuracy for predicting pulmonary hypoplasia was achieved using the 3D lung volume measurements versus gestational age (sensitivity 83%, specificity 100%, positive predictive value 100% and negative predictive value 92%). Conclusions Three‐dimensional lung volume measurements seem to be promising in predicting pulmonary hypoplasia prenatally in pregnancies complicated by PPROM. Copyright © 2006 John Wiley & Sons, Ltd.