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Amniotic trisomy 11 mosaicism—is it a benign finding?
Author(s) -
BaselVanagaite Lina,
Davidov Bella,
Friedman Jane,
Yeshaya Yosefa,
Magal Nurit,
Drasinover Valerie,
Shohat Mordechai
Publication year - 2006
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1501
Subject(s) - amniocentesis , uniparental disomy , trisomy , prenatal diagnosis , amniotic fluid , fetus , aneuploidy , fluorescence in situ hybridization , karyotype , chorionic villus sampling , medicine , biology , obstetrics , pathology , chromosome , pregnancy , genetics , gene
Objectives A case of prenatally diagnosed trisomy 11 mosaicism with a normal outcome is reported and the medical literature on prenatal detection of this finding is reviewed. Methods Proportion of cells with trisomy 11 was evaluated in amniocytes, fetal blood lymphocytes, newborn fibroblasts and urinary epithelial cells. Karyotype studies and fluorescence in situ hybridization analysis using the 11q13LS1 CCND1 probe were performed. Results Trisomy 11 level III mosaicism of 26% was detected in amniotic fluid cells. Periumbilical blood sampling showed a normal fetal karyotype. No fetal structural abnormalities were noted on ultrasound scan. The infant was spontaneously delivered and had normal physical findings at birth. No evidence of trisomic cells was found on extensive postnatal evaluation, implying an extraembryonic origin. Molecular analysis excluded uniparental disomy of chromosome 11. At 1 year of age, the baby is developing normally. Conclusions Only three reports on trisomy 11 mosaicism identified at amniocentesis have been published previously, all with a normal outcome. Additional cases of prenatally diagnosed mosaicism for trisomy 11 are necessary to assess more accurately the clinical significance of this finding. Copyright © 2006 John Wiley & Sons, Ltd.