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Twin pregnancy with a chimeric androgenetic and biparental placenta in one twin displaying placental mesenchymal dysplasia phenotype
Author(s) -
Surti Urvashi,
Hill Lyndon M.,
Dunn Jeanette,
Prosen Tracy,
Hoffner Lori
Publication year - 2005
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1255
Subject(s) - twin pregnancy , placenta , conceptus , zygote , obstetrics , pregnancy , fetus , prenatal diagnosis , biology , spontaneous conception , gynecology , andrology , medicine , genetics , embryo , infertility , embryogenesis
Objectives The aim was to report an unusual trizygotic pregnancy that resulted in live‐born twins. The placenta of one twin had placental mesenchymal dysplasia (PMD), which resulted from a chimeric fusion of an androgenetic zygote and a normal biparental zygote. The literature review was summarized. Methods The case was first detected by prenatal ultrasound, and was then followed by a histologic and detailed genetic investigation. The literature on PMD, complete hydatidiform moles (CHMs), and placental mosaicism and chimerism was also reviewed. Results One placenta of a twin pregnancy was noted to be diffusely cystic and enlarged. The macroscopic and microscopic findings were consistent with the diagnosis of PMD; however, genetic findings confirmed confined placental chimerism involving a normal biparental 46,XY male conceptus and an androgenetic 46,XX complete hydatidiform mole. Conclusions This case represents a rare placental abnormality, PMD, which may have a diverse etiology. Therefore, detailed histologic and genetic analysis were performed for an accurate diagnosis. Copyright © 2005 John Wiley & Sons, Ltd.