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Maternal serum activin A and inhibin A in trisomy 18 pregnancies at 10–14 weeks
Author(s) -
Spencer Kevin,
Liao Adolfo W.,
Ong Charas Y. T.,
Flack Nicola J.,
Nicolaides Kypros H.
Publication year - 2001
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.125
Subject(s) - trisomy , gestation , endocrinology , pregnancy associated plasma protein a , medicine , down syndrome , aneuploidy , pregnancy , andrology , biology , first trimester , biochemistry , genetics , psychiatry , gene , chromosome
In 45 cases of trisomy 18 and 493 control pregnancies at 10–14 weeks of gestation, maternal serum inhibin A, total activin A, free β‐hCG and PAPP‐A were measured. In the trisomy 18 pregnancies the median values were 0.74 MoM for inhibin A, 1.23 MoM for activin A, 0.38 MoM for free β‐hCG and 0.16 MoM for PAPP‐A. The degree of deviation from normal in the levels of inhibin and activin is small in comparison with free β‐hCG and PAPP‐A and they are therefore unlikely to be of value in improving the sensitivity of 90% for a 1% false‐positive rate achieved by screening with fetal nuchal translucency and maternal serum free β‐hCG and PAPP‐A. Copyright © 2001 John Wiley & Sons, Ltd.