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A unique case of der(11)t(11;22),‐22 arising from 3:1 segregation of a maternal t(11;22) in a family with co‐segregation of the translocation and breast cancer
Author(s) -
Jobanputra Vaidehi,
Chung Wendy K.,
Hacker April M.,
Emanuel Beverly S.,
Warburton Dorothy
Publication year - 2005
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.1196
Subject(s) - chromosomal translocation , monosomy , gestation , fetus , biology , pregnancy , gynecology , karyotype , andrology , obstetrics , genetics , medicine , chromosome , gene
Objective To report the first tertiary monosomy in a pregnancy loss to a female t(11;22) carrier. Methods The patient was a 34‐year‐old G10P1 female known to have a balanced translocation t(11;22)(q23;q11.2). She had one female livebirth (a translocation carrier) and eight miscarriages. Five female relatives known to be translocation carriers had a history of breast cancer, three of them premenopausally. The patient herself had a malignant melanoma. Results During the 10th pregnancy, ultrasound showed a viable embryo at 6 weeks of gestation, but loss of embryonic heartbeat by 7.5 weeks. Culture of the products of conception at 8 weeks of gestation showed the karyotype: 46,XY,+2,der(11)t(11;22)(q23;q11.2)mat,‐22[4]/45,XY,der(11)t(11;22)(q23;q11.2)mat,‐22[4], resulting from fertilization of the maternal 3:1 segregation product containing only the der(11) by a normal gamete. Subsequently, she became pregnant with a normal 46,XX fetus. FISH analysis indicated that the breakpoints on 11q and 22q in the patient were in the previously described region common to typical recurrent t(11;22). In addition, a nested‐PCR‐based approach showed that they were located within the same palindromic AT‐rich sequence previously described. Conclusion This case demonstrates that the tertiary monosomy resulting from the 3:1 segregation is compatible with embryonic survival into the first trimester. It is also another example of apparent association of the constitutional translocation t(11;22) and breast cancer. Copyright © 2005 John Wiley & Sons, Ltd.